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Acridine Derivatives as Chemotherapeutic Agents

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Acridine derivatives are one of the oldest classes of bioactives, widely used as antibacterial and antiprotozoal agents. Some work in these areas continues, but recent research has focused mainly on their use as anticancer drugs, because of the ability of the acridine chromophore to intercalate DNA and inhibit topoisomerase enzymes.
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Keywords: acridine; antibacterial; anticancer drugs; charge-transfer interactions; chemotherapeutic agents; efficient mutagen; high therapeutic indices; human breast cancer cell lines; kinetics; mode of binding

Document Type: Review Article

Publication date: 2002-09-01

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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