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Vasculogenesis and Angiogenesis Depend on the Developmental Origin in the Arterial Tree

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Recent advances in growth factor therapy for the treatment of ischemic disease of the heart and peripheral vasculature offer hope for a novel strategy that is based on the generation of a new blood supply. Members of the fibroblast growth factor and vascular endothelial growth factor families and several other molecules have all been shown to induce significant angiogenesis in animal models of acute or chronic, myocardial or peripheral ischemia. In addition, it is known that arteries from specific regions in the arterial tree have various developmental origins. This may be one explanation for why arteries of different parts of the arterial tree undergo differential changes during the pathogenesis of vascular disease. There is speculation over several fundamental questions concerning the origin of vessel wall cells and the mechanisms that regulate their development and differentiation.

Here we discuss what is known to date about the differential developmental origin of arteries and the possible consequences for therapeutic angiogenesis.

Keywords: angiogenic processes; cytoskeletal markers desmin; disrupted cell contact; fibroblast growth; hematopoietic progenitors; ischemic disease; mesenchymal transition failures; mesodermal tissue; smooth muscle cells; vascular endothelial cells

Document Type: Review Article


Publication date: September 1, 2002

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

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