Non-peptide Opioid Receptor Ligands - Recent Advances. Part II - Antagonists
Authors: Kaczor, A.; Matosiuk, D.
Source: Current Medicinal Chemistry, Volume 9, Number 17, September 2002 , pp. 1591-1603(13)
Publisher: Bentham Science Publishers
Abstract:This paper is the second part of the review on opioid receptor ligands and deals with the progress in the field of non-peptide opioid receptor antagonists (starting from the pioneering opiate studies in the early seventies) with particular stress on the last decade accomplishments.
As X-ray high resolution structure determination of the ligand-receptor systems for G protein-coupled receptors meets with considerable experimental obstacles, the knowledge about ligand interactions with the membrane-bound receptors traditionally derives from structure-activity studies. Hence, such a concise summary, collecting chemically distinct but pharmalogically relative compounds, may be a convenient information source for any research concerning ligand-opioid receptor binding or rational drug design.
Document Type: Review Article
Publication date: September 2002
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