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Non-peptide Opioid Receptor Ligands - Recent Advances. Part II - Antagonists

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This paper is the second part of the review on opioid receptor ligands and deals with the progress in the field of non-peptide opioid receptor antagonists (starting from the pioneering opiate studies in the early seventies) with particular stress on the last decade accomplishments.

As X-ray high resolution structure determination of the ligand-receptor systems for G protein-coupled receptors meets with considerable experimental obstacles, the knowledge about ligand interactions with the membrane-bound receptors traditionally derives from structure-activity studies. Hence, such a concise summary, collecting chemically distinct but pharmalogically relative compounds, may be a convenient information source for any research concerning ligand-opioid receptor binding or rational drug design.
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Keywords: de novo methodology; kappa opioid receptor; non-peptide opioid receptor; norbinaltorphimine derived ligands; pharmacophore models; pyrrolomorphinans

Document Type: Review Article

Publication date: 2002-09-01

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