Valproate and Valproate-Analogues: Potent Tools to Fight Against Cancer

Authors: Blaheta R.A.; Nau H.; Michaelis M.; Cinatl.Jr J.

Source: Current Medicinal Chemistry, Volume 9, Number 15, August 2002 , pp. 1417-1433(17)

Publisher: Bentham Science Publishers

Buy & download fulltext article:

Price: $63.10 plus tax (Refund Policy)

Abstract:

The branched-chain fatty acid valproic acid (VPA) is the most commonly used antiepileptic drug for treating generalized epilepsy. Although originally considered to be of low toxicity, VPA has proved to possess considerable teratogenic potential when applied to the pregnant epileptic women. During the last few years, it has become evident that some of the mechanisms which account for the malformations produced by VPA are related to distinct anti-tumor properties of this compound. This intriguing discovery opens novel aspects for the treatment of tumor patients. In the present review, the biological, biochemical and pharmacological properties of VPA are discussed. Analyses of structure-activity relationships can provide the necessary insight into the molecular structures responsible for the anti-tumor effects.

Keywords: valproate; valproate-analogue; propyl-4-yn-valproic acid; heptyl-4-yn-valproic acid

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/0929867023369763

Publication date: 2002-08-01

More about this publication?

Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.