Effect of Alpha-FMH and DPPE on Colony-forming Properties of Human Peripheral Progenitor Cells

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Abstract:

Endogenous histamine regulates the haematopoiesis. Histidine decarboxylase inhibitor decreases the histamine level, and its intracellular antagonist decreases the histamine effect.

The effect of histidine decarboxylase inhibitor (α-fluoromethyl histidine) and the intracellular antagonist of histamine [N'N-diethyl-2-4-(phenylmethyl) phenoxyethan-amine-HCl] was investigated on the colonyforming ability of human peripheral progenitor cells. Semi-solid culture medium was used both in the presence and in the absence of 3 U / ml erythropoietin.

α-Fluoromethyl histidine was used in the range of 50 through 150 μ Mol / ml, the concentration of N'N-diethyl- 2-4-(phenylmethyl) phenoxyethanamine-HCl was between 5 and 25 μ Mol / ml.

The number of both the erythroide and the granulocyte macrophage colony was significantly decreased in a concentration dependent manner by the presence of both N'N-diethyl-2-4-(phenylmethyl) phenoxyethanamine-HCl (in all concentrations used) and α-fluoromethyl histidine (at higher concentration). The inhibitory effect was decreased by erythropoietin.

Keywords: alpha-fmh; bfu-e; cfu-gm; dppe; peripheral progenitor cell

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/0929867023369899

Publication date: July 1, 2002

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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