Skip to main content

Effect of Alpha-FMH and DPPE on Colony-forming Properties of Human Peripheral Progenitor Cells

Buy Article:

$63.00 plus tax (Refund Policy)


Endogenous histamine regulates the haematopoiesis. Histidine decarboxylase inhibitor decreases the histamine level, and its intracellular antagonist decreases the histamine effect.

The effect of histidine decarboxylase inhibitor (α-fluoromethyl histidine) and the intracellular antagonist of histamine [N'N-diethyl-2-4-(phenylmethyl) phenoxyethan-amine-HCl] was investigated on the colonyforming ability of human peripheral progenitor cells. Semi-solid culture medium was used both in the presence and in the absence of 3 U / ml erythropoietin.

α-Fluoromethyl histidine was used in the range of 50 through 150 μ Mol / ml, the concentration of N'N-diethyl- 2-4-(phenylmethyl) phenoxyethanamine-HCl was between 5 and 25 μ Mol / ml.

The number of both the erythroide and the granulocyte macrophage colony was significantly decreased in a concentration dependent manner by the presence of both N'N-diethyl-2-4-(phenylmethyl) phenoxyethanamine-HCl (in all concentrations used) and α-fluoromethyl histidine (at higher concentration). The inhibitory effect was decreased by erythropoietin.

Keywords: alpha-fmh; bfu-e; cfu-gm; dppe; peripheral progenitor cell

Document Type: Review Article


Publication date: July 1, 2002

More about this publication?
  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

Access Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more