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Bisphosphonate Prodrugs

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Bisphosphonates (BP) are pyrophosphate analogs having a P-C-P backbone. The oral bioavailability of BPs is ca. 1%, due to high ionisation at physiological pH. Using the prodrug approach, oral absorption can be increased by masking one or more ionizable groups (clodronate, etidronate), or using a targeting carrier system (alendronate, pamitronate).

Keywords: bisphosphonate; clodronate; etidronate; pyrohosphate analogs

Document Type: Review Article


Publication date: 2002-06-01

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