Bisphosphonate Prodrugs

Author: Vepsalainen J.J.

Source: Current Medicinal Chemistry, Volume 9, Number 12, June 2002 , pp. 1201-1208(8)

Publisher: Bentham Science Publishers

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Abstract:

Bisphosphonates (BP) are pyrophosphate analogs having a P-C-P backbone. The oral bioavailability of BPs is ca. 1%, due to high ionisation at physiological pH. Using the prodrug approach, oral absorption can be increased by masking one or more ionizable groups (clodronate, etidronate), or using a targeting carrier system (alendronate, pamitronate).

Keywords: pyrohosphate analogs; bisphosphonate; clodronate; etidronate

Language: English

Document Type: Review article

DOI: 10.2174/0929867023369998

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