-Secretase as a Therapeutic Target for Inhibitor Drugs

Authors: Ghosh A.K.; Hong L.; Tang J.

Source: Current Medicinal Chemistry, Volume 9, Number 11, June 2002 , pp. 1135-1144(10)

Publisher: Bentham Science Publishers

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Abstract:

Recent identification of bgr -scretasse being a membrane-associated aspartic protease has stimulated strong interest on this enzyme as a therapeutic target for Alzheimer's disease. Here we review the current understanding in the structure-function relationship as well as the status in the design of its inhibitors of this protease, memapsin 2 (BACE, ASP-2). The development in the basic tools, such as the preparation of recombinant memapsin 2, the assay method for kinetic measurements of inhibition, the determination of the subsite specificity and the crystal structure of memapsin 2 complexed to a tight-binding inhibitor, has made the structural based inhibitor design possible. More recent inhibitors, having Ki values in the nanomolar range and molecular size in low 700 Da, show some promise that clinically useful inhibitors of bgr -scretasse may be attainable.

Keywords: beta secretase; beta secretase and inhibitor; memapsin 2; asp-2

Language: English

Document Type: Review article

DOI: 10.2174/0929867023370149

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