Non Steroidal Anti-Inflammatory and Anti-Allergy Agents
In addition, active oxygen species (AOS) including superoxide anion (O2-), hydrogen peroxide, hydroxyl radical and ferric radical, mediate cell damage in a variety of pathophysiological conditions and are responsible for oxidative injury of enzymes, lipid membranes and DNA in living cells and tissues. Prostaglandins and leukotrienes in the arachidonate pathway linked with lipid peroxidation may amplify the oxidative damage. Nirtric oxide (NO) plays also a role as an efector in inflammation, since PG and NO thought to be important in maintaining mucosal integrity.
Dual or selective inhibitors, specific receptor antagonists, AOS scavengers, and NO donors have been under development for therapeutic application. Several classes of inhibitors have been identified and at least 12 major chemical series are known to affect PGs production directly.
In this review, we account on our research work concerning NSAIDs combined with a reference of the recent literature.
Keywords: 5-lipoxygenase (5-LOX); Anti-Allergy Agents; Nirtric oxide (NO); Non Steroidal Anti-Inflammatory; active oxygen species (AOS); arachidonic acid (A.A); cycloxygenase (COX); lipoxygenase (LOX)
Document Type: Review Article
Publication date: 2002-01-01
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