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New Trends in Extraction, Identification and Quantification of Artemisinin and its Derivatives

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Abstract:

Artemisinin, a sesquiterpene lactone endoperoxide, and a number of its precursors, metabolites and semisynthetic derivatives have shown to possess antimalarial properties. Several methods have been reported for the measurement of artemisinin and its main derivatives in plant material and biological fluids. However, most of them are either not sufficiently sensitive and do not offer reliable results, or are difficult to apply in routine analyses. Therefore, new m ethods for the determination of these compounds, such as supercritical fluid extraction and chromatography, pressurized solvent extraction, microwave-assisted extraction, high-performance liquid chromatography coupled to mass spectrometry or evaporative light scattering detection, will be presented. Applications to plant material, pharmaceutical formulations and biological fluids will also be reviewed.

Keywords: A. annua; Artemisia annua; Artemisinin; CAPILLARY ELECTROPHORESIS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EVAPORATIVE LIGHT SCATTERING DETECTOR; HPLC-MS; HPLC-UV; Microwave-assisted Extraction; Pressurized solvent extraction (PSE); TANDEM MASS SPECTROMETRY; Thermolysis; arteannuin B; artemisinic acid; artemisitene; dihydroartemisinin

Document Type: Review Article

DOI: https://doi.org/10.2174/0929867013371563

Publication date: 2001-12-01

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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