New Trends in Extraction, Identification and Quantification of Artemisinin and its Derivatives
Abstract:Artemisinin, a sesquiterpene lactone endoperoxide, and a number of its precursors, metabolites and semisynthetic derivatives have shown to possess antimalarial properties. Several methods have been reported for the measurement of artemisinin and its main derivatives in plant material and biological fluids. However, most of them are either not sufficiently sensitive and do not offer reliable results, or are difficult to apply in routine analyses. Therefore, new m ethods for the determination of these compounds, such as supercritical fluid extraction and chromatography, pressurized solvent extraction, microwave-assisted extraction, high-performance liquid chromatography coupled to mass spectrometry or evaporative light scattering detection, will be presented. Applications to plant material, pharmaceutical formulations and biological fluids will also be reviewed.
Keywords: A. annua; Artemisia annua; Artemisinin; CAPILLARY ELECTROPHORESIS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EVAPORATIVE LIGHT SCATTERING DETECTOR; HPLC-MS; HPLC-UV; Microwave-assisted Extraction; Pressurized solvent extraction (PSE); TANDEM MASS SPECTROMETRY; Thermolysis; arteannuin B; artemisinic acid; artemisitene; dihydroartemisinin
Document Type: Review Article
Publication date: 2001-12-01
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