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The Inhibitory Neural Circuitry as Target of Antiepileptic Drugs

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Abstract:

Impairments and defects in the inhibitory neurotransmission in the CNS can contribute to various seizure disorders, i.e., gama-aminobutyric acid (GABA) and glycine as the main inhibitory neurotransmitters in the brain play a crucial role in some forms of epilepsy. Recent advances in deciphering the molecular basis of the GABAergic and glycinergic systems has been achieved by means of cloning techniques and gene targeting strategies in animals, contributing to the understanding of drug action. As well, several anticonvulsive substances emerged which target key molecules of the inhi- bitory systems. Employment of recombinant expression systems, including, but not restricted to the inhibitory circuitry, will further facilitate drug screening and rational approaches to design novel specific antiepileptic drugs, which act highly efficiently to prevent or reduce generation and spread of seizures.

Keywords: Antiepileptic Drugs; Gabapentin; Ginkgo biloba; Glycine receptor; aminobutyric acid (GABA); epilepsy; glutamate decarboxylase; succinic semialdehyde dehydrogenase; valproate

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/0929867013372319

Publication date: September 1, 2001

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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