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Candida Proteases and Their Inhibition Prospects for Antifungal Therapy

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Abstract:

The rationale for inhibition of the secreted acid proteases (SAP) of Candida fungal species as a novel antifungal strategy is outlined. Enzyme structure-activity relationship data regarding the inhibitor A-70450 are described along with results from in vivo antifungal assays. Developments from protein X-ray crystallographic studies, SAP knock-out genetic studies, and the importance of these new results for drug discovery are reviewed. Finally, inhibition of the Candida SAP enzymes with HIV protease inhibitors and a proposed role in candidiasis of AIDS patients is discussed.

Keywords: Antifungal Therapy; Candida Proteases; Candida fungal species; HIV PROTEASE INHIBITORS; amphotericin; echinocandin B; fluconazole; secreted acid proteases (SAP)

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/0929867013372698

Publication date: July 1, 2001

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

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