Skip to main content

Reproductive Toxins Pervasive Theme of Oxidative Stress and Electron Transfer

Buy Article:

$63.00 plus tax (Refund Policy)

Abstract:

Reproductive toxicity has been a topic of increasing interest and concern in recent years, generating controversy in association with danger to humans and other living things. A veritable host of chemicals is known to be involved, encompassing a wide variety of classes, both organic and inorganic. Exposure is pervasive and virtually unavoidable due to contamination of air, water, ground, food, beverages, drugs, and household items. The corresponding adverse effects on reproduction are numerous. There is uncertainty regarding mode of action although various theories have been advanced, e.g., disruption of the CNS, DNA attack, enzyme inhibition, interference with hormonal action, and insult to membranes and proteins.

This review provides extensive evidence for involvement of oxidative stress (OS) and electron transfer (ET) as a unifying theme. Successful application is made to all of the main classes of toxins, in addition to large numbers of miscellaneous types. We believe it is not coincidental that the vast majority of these substances incorporate ET functionalities (quinone, metal complex, ArNO 2 , or conjugated iminium) either per se or in metabolites, potentially giving rise to reactive oxygen species (ROS) by redox cycling. Some categories, e.g., peroxides and radiation, appear to generate ROS by non-ET routes. For completeness, other theories are also addressed; a multifaceted approach appears to be the most logical. Our framework should increase understanding and contribute to preventative measures, such as use of antioxidants (AOs). The ET-OS theory has recently been used as the central theme by us in reviews of biomechanisms involved with anti-infective drugs, anticancer agents, and carcinogens (see text).

Keywords: Fungicides; METALS; Organophosphates; PESTICIDES; Pentachlorophenol; Pyrethroids; RADIATION; Reproductive Toxins; antioxidants (AOs).; reactive oxygen species (ROS)

Document Type: Review Article

DOI: https://doi.org/10.2174/0929867013372878

Publication date: 2001-06-01

More about this publication?
  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
  • Access Key
  • Free ContentFree content
  • Partial Free ContentPartial Free content
  • New ContentNew content
  • Open Access ContentOpen access content
  • Partial Open Access ContentPartial Open access content
  • Subscribed ContentSubscribed content
  • Partial Subscribed ContentPartial Subscribed content
  • Free Trial ContentFree trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more