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The 2-Chlorotrityl Resin a Worthy Addition to the Medicinal Chemist's Toolbox

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Abstract:

The polystyrene-based 2-chlorotrityl resin was originally used in the synthesis of peptides using an Fmoc-amino acid(slash)carboxyl-linked protocol. While traditionally employed to prepare a number of biologically active peptides, the resin has received increasing attention as a support for the synthesis of pseudopeptide and non-peptide molecules recently. This review focuses on 2-chlorotrityl resin-supported synthesis of small molecules that collectively display a broad range of biological activities.

Keywords: Anti-infective agents; Enzyme inhibitors; Nuclear Receptor Modulators; Polystyrene-based 2-chlorotrityl resin; Synthesis of peptide; The 2-Chlorotrityl Resin

Document Type: Review Article

DOI: https://doi.org/10.2174/0929867013373192

Publication date: 2001-05-01

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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