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Targeting Double Stranded DNA with Peptide Nucleic Acid (PNA)

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Abstract:

PNA (peptide nucleic acid) is a DNA mimic with a pseudopeptide (polyamide) backbone which can be used to target double stranded DNA with high sequence specificity. PNA therefore has great potential in the development of biomolecular tools for manipulation of DNA as well as for the development of DNA targeted gene therapeutic drugs. The status of this field is discussed in terms of PNA binding modes and mechanism as well as applications.

Keywords: Antigene Drugs; Binding Mechanism; Duplex Invasion; Genetic Manipulation; Ionic Strength Dependence; Peptide Nucleic Acid; Stranded DNA

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/0929867003373373

Publication date: May 1, 2000

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
ben/cmc/2001/00000008/00000005/art00006
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