DNA Minor Groove Alkylating Agents

Author: Denny W.A.

Source: Current Medicinal Chemistry, Volume 8, Number 5, May 2001 , pp. 533-544(12)

Publisher: Bentham Science Publishers

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Abstract:

Recent work on a number of different classes of anticancer agents that alkylate DNA in the minor groove is reviewed. There has been much work with nitrogen mustards, where attachment of the mustard unit to carrier molecules can change the normal patterns of both regio- and sequence-selectivity, from reaction primarily at most guanine N7 sites in the major groove to a few adenine N3 sites at the 3-end of poly(A(slash)T) sequences in the minor groove. Carrier molecules discussed for mustards are intercalators, polypyrroles, polyimidazoles, bis(benzimidazoles), polybenzamides and anilinoquinolinium salts. In contrast, similar targeting of pyrrolizidine alkylators by a variety of carriers has little effect of their patterns of alkylation (at the 2-amino group of guanine). Recent work on the pyrrolobenzodiazepine and cyclopropaindolone classes of natural product minor groove binders is also reviewed.

Keywords: DNA Minor Groove Alkylating Agents; Intercalators; Polybenzamides; Anilinoquinolinium; Polypyrroles; Pyrrolizidines; CBI compounds

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/0929867003373283

Publication date: 2001-05-01

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Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.