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Sequence Recognition of DNA by Lexitropsins

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Abstract:

Lexitropsins are modular polyamide molecules that are designed to read the base sequence of DNA. Lexitropsins constructed of three types of subunits-pyrrole, imidazole and hydroxypyrrole-allow full recognition of DNA base sequences. Structural studies have revealed the atomic basis of this specificity. Theoretical studies have explored the effectiveness of lexitropsins in targeting a given sequence within a genome, and have been used to analyze and improve lexitropsin design.

Keywords: DNA; Distamycin; Lexitropsins; Netropsin; Sequence Recognition

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/0929867003373319

Publication date: May 1, 2001

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
ben/cmc/2001/00000008/00000005/art00003
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