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A Role for the Anti-Inflammatory Properties of Tetracyclines in the Prevention of Acute Lung Injury

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The etiology of inflammatory disorders involves many cellular, plasmatic and humoral pathways of signaling culminating in the production of enzymatic and free radical mediated tissue damage. Multiple redundant pathways of initiation and elusive temporal expression of initiators pose formidable barriers to effective treatment. Nowhere is this more evident than in the adult respiratory distress syndrome (ARDS), a systemic inflammatory disorder leading to pulmonary failure where, despite significant advances in intensive care management, mortality has improved only 10 percent over the last decade. Tetracyclines, in addition to their anti-microbial properties, exhibit inhibitory activity toward several initiators of the inflammatory cascade and mediators of tissue damage. In this review we discuss how the broad spectrum anti-inflammatory properties of the tetracyclines make them attractive candidates for use in the prevention of acute lung injury.
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Keywords: ECM hydrolysis; Ne induced breakdown; adult respiratory distress syndrome; alveolar capilary basement; antiinflammatory properties; bronchoalveolar lavage; matrix metalloproteinases; membrane anchored pro TNF; neutrophil elastase; pro inflammatory mediator; short lived messenger molecule; tetracyclines

Document Type: Review Article

Publication date: 01 February 2001

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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