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Biologic Properties of Non-Antibiotic, Chemically Modified Tetracyclines (CMTs): A Structured, Annotated Bibliography

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The first paper reporting on a potentially important medical property of a non-antimicrobial tetracycline appeared in 1987. Since then, a literature of over 75 papers has supported the therapeutic potential of this class of compounds. In this review, this literature is grouped and organized with commentary on the data which has been published to date. The biomedical applicability of these discoveries obviously covers a wide range of medical conditions and clearly justifies their continued development.
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Keywords: Cartilage degradation; Enhance cytokine; Modified tetracycline; Non Antibiotics; animal models; antimicrobial properties; arthritic dog; cmts inhibit MMP 13; collagenolytic activity; enzyme inhibition; induce apoptosis; metabolic bone disease; non specific proteolysis

Document Type: Review Article

Publication date: 2001-02-01

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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