Novel Approaches for Designing 5'-O-Ester Prodrugs of 3'-Azido-2'3'-dideoxythymidine (AZT)
Keywords: (Acyloxy) Alkyl; (HIV) infection; 1,4-Dihydro-1-methyl-3-[(pyridylcarbonyl)oxy]ester; 1,4-dihydro-1-methyl-3-pyridinylcarboxylic acid; 2'3'-Dideoxynucleosides; 3'-Azido-2'3'-dideoxythymidine (AZT); 5'-O-Aliphatic derivatives of AZT; 5'-O-Ester prodrugs; 5'-O-Myristoyl derivatives of AZT; AZT Masked phosphate prodrugs; AZT monophosphate, diphosphate and triphosphate di; Adamantane Conjugates; Amino acid ester; Aryl phosphate trimesters of AZT; Aspirin (O-acetylsalicylic acid) prodrug of AZT; Bicyclam-AZT Conjugates; Bis (S-Acyl-2-thioethyl) (SATE) esters of AZT-MP [; Carbohydrate Derivatives; Carbohydrate Ester Derivatives; Carboxylic Esters (13-64); Cyclosaligenyl-AZT; Dialkyl phosphotriester derivatives; Diaryl phosphotriester derivatives; Dinucleoside phosphate derivatives; Ether Lipids (Els); Foscarnet derivatives of AZT; Glycolate and lactate phosphotriesters; Immunodeficiency virus; Inhibitors of viral reverse transcriptase (RT); Long chain polyunsaturated fatty acid analogs; Monoalkyl or Monoarylphosphate derivatives of AZT; Phosphodiesters of AZT; Phosphoramidate derivatives; Phosphormaidate derivatives; Phosphotriesters; Polyunsaturated aliphatic acid; Steroid Esters; Steroidal phosphotriester derivatives; cyclic 5'-O-carboxylic acids; dinucleoside phosphate derivatives
Document Type: Review Article
Publication date: 01 October 2000
- Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.