Molecular Manipulation of G Protein coupled Receptors A New Avenue into Drug Discovery
Drug discovery is aiming to produce highly specific compounds based on subtle definition of receptor subtypes which can best be studied using heterologous expression of wild type or mutated forms of cDNA or genes encoding these proteins. Furthermore, new therapeutic opportunities may be provided by investigation of orphan receptors, the natural ligands for which remain unidentified. Some human diseases have been shown to be associated with rare mutations of GPCRs and the possibility that widely distributed polymorphisms in GPCR genes may allow selective therapeutic strategies for population subgroups is driving the development of the science of pharmacogenetics.
Keywords: G protein coupled receptors; GPCR; GPCR Polymorphisms; Luteinising hormone; Orphan Receptors; Plasma membrane; cDNA; cholecystokinin; gene; ligand bidning domains; neuropeptide Y; thyroid stimulatin hormone
Document Type: Review Article
Publication date: 2000-09-01
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