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New Chemical and Biological Aspects of S-Nitrosothiols

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Nitric oxide (NO) possesses many physiological effects and S-nitrosothiols have been identified in a variety of tissues exhibiting many NO-like activities. This review focuses on the latest discoveries pertaining to the biological functions of S-nitrosothiols and the recent research progress in the chemical properties and biomedical applications of RSNOs.

Keywords: Cu Zn superoxide dismutase; Drug SNO conjugates; RSNOs; S Nitroso 1 thiolsugars; S nitrosopeptides; S nitrosothiols; TGSNO; adrenergic receptor; apotosis; blood flow regulation; cardiac calcium release channel; cyclic nucleotide gated channel; disulfide; glucopyranose; inducible nitric oxide synthase; interleukin converting enzyme; nitric oxide NO; perinatal circulatory transition; platelet neutrophil interaactions; s Nitrosohemoglobin; s Nitrosothiol; superoxide catalzed RSNO; thiyl radical; xanthine oxidase

Document Type: Review Article


Publication date: August 1, 2000

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  • Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.

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