Approaches to the Design of Effective HIV-1 Protease Inhibitors
Keywords: HIV portease dimers; N terminus sequences; acquired immunodeficiency syndrome AIDS; antifungal antibiotic cerulenin; aspartic protease group; crystallographic studies; crystalographic structure; difluoroketones; dimerization inhibitors; glutathionation experiments; heterodimer formation; hydrohobicity; lipophilicity; metal organic complexses; non cleavable transition state; polyporteins gag m RNA; protease inhibitors; rational drug design; substrate backbone; substrate based approach; transition state isosteres; trystallographic complexes
Document Type: Review Article
Publication date: 2000-04-01
- Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.