Huperzine A, A Potential Therapeutic Agent for Treatment of Alzheimer's Disease
Recently, it has been reported that HupA could reduce neuronal cell death caused by glutamate. The dual bio-activities of HupA would further enhance its value and potentiality as the therapeutic agent for Alzheimers disease.
Keywords: HupA; Huperzia serrata; SAR studies; alzheimer s disease; brain receptor; chiral catalyst; cyvlohexanedione mono ethylene ketal 10; diastereomeric separation; dimethyl 4 oxopimelate; donepezil; dual bio activities; enantiomer excess; enantioselective palladium catalyzed bicycloannula; entgegen; glutamate; huperzine A; inhibitor of AChE; keto ester; learning; lithium aluminium hydride; lycopoduim; memory; natura HupA; neuronal cell death; pharmacological actions; pyridine derivatives; recemic HupA; rectus; revesibile inhibitors if AChE; sinister left; stereiselective michael aldok reaction; structure activity relationships; structure elucidation; tetramethylguanidine; the anti AChE activities; total synthesis; zusammen together
Document Type: Review Article
Publication date: 01 March 2000
- Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.