Inhibitors of Mammalian Central Nervous System Selective Amino Acid Transporters

Author: Armer R.E.

Source: Current Medicinal Chemistry, Volume 7, Number 2, February 2000 , pp. 199-209(11)

Publisher: Bentham Science Publishers

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Abstract:

Central nervous system (CNS) selective amino acid transporters provide an important function in maintaining tonic extracellular levels of amino acids that act as neurotransmitters, synaptic modulators or neurotransmitter precursors. Small molecule inhibitors of these transporters have been postulated and in some cases demonstrated to be useful in the treatment of a range of CNS driven disorders such as epilepsy, anxiety, psychosis, depre-ssion, pain and neurodegenerative disease. Although much of the research to date in this field has focussed on inhibition of the g -amino butyric acid (GABA) transporters more recent reports have also generated interest in modulation of glycine, glutamate and proline transporters. This article will review the current medicinal chemistry literature and structure activity relationships known for mammalian CNS selective amino acid transporters.

Keywords: inhibitors; mammalian central nervous system; amino butyric acid GABA transporters; GAT1; Glycine transporter; proline transporter; taurine transporter; cationic amino acid transporters; glutamate transporters

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/0929867003375380

Publication date: 2000-02-01

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Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews written by leaders in the field covering a range of the current topics in medicinal chemistry. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.