Authors: Bourinbaiar, Aldar S.; Jirathitikal, Vichai; Silin, Dmytro S.; Lu, Nian-Qing; Abulafia-Lapid, Rivka

Source: Current Immunology Reviews, Volume 3, Number 2, May 2007 , pp. 101-107(7)

Publisher: Bentham Science Publishers

Abstract:

It may appear that problems of reproductive immunology have little in common with issues of treatment and prevention of AIDS. However, the certain aspects of HIV immunopathogenesis are closely related to problems faced by reproductive immunologists. The development of prophylactic and therapeutic AIDS vaccines would greatly benefit from acquired experience in immune regulation of reproductive dysfunction. The spermatozoa and HIV are foreign intruders that must enter the host cell, oocyte or T-lymphocyte, in order to start the replication process. The immune responses of the host organism against fertilized egg or HIV-impregnated lymphocyte must be similar, since in theory they are directed against alloantigens presented by such cells. This paper attempts to bring together the recent advances in AIDS field with progress made in the physiology and pathology of reproduction in humans, especially in the domain of immunotherapy and prevention of recurrent spontaneous abortions (RSA). It is our opinion that the lessons learned from alloimmunization trials of infertile women are relevant to prophylactic and therapeutic strategies for HIV infection.

Keywords: Alloimmunization; fertility; immunoglobulin; T lymphocyte; miscarriage; RSA; vaccine

Document Type: Research article

DOI: http://dx.doi.org/10.2174/157339507780655531

Affiliations: 1: Immunitor USA Inc., College Park, MD 20740, USA.

Publication date: 2007-05-01

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• Current Immunology Reviews publishes frontier reviews on all the latest advances in clinical immunology. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in clinical immunology.

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