Authors: Olearczyk, Jeffrey J.; Imig, John D.

Source: Current Hypertension Reviews, Volume 1, Number 3, November 2005 , pp. 235-242(8)

Publisher: Bentham Science Publishers

Abstract:

Nephropathy developing from hypertension and/or non-insulin dependent diabetes mellitus (NIDDM) is becoming increasingly prevalent in the world population. Although there is a significant amount of research being conducted in this area, the etiologies of nephropathy are not known. It has been proposed that hemodynamic and metabolic alterations in the kidney contribute to the development and progression of nephropathy. More interesting however, is the identification of an inflammatory component to nephropathy that is characterized by increased expression of nuclear transcription factors, increased cytokine expression and interstitial cell infiltration. Cytochrome P450 epoxygenase metabolites have recently been reported to regulate sodium excretion as well as renal blood flow and blood pressure. In addition, the epoxyeicosatrienoic acids (EETs) have been identified as anti-inflammatory mediators. We propose that EETs can prevent the development and progression of nephropathy associated with NIDDM and hypertension, by inhibiting the expression of pro-inflammatory genes.

Keywords: cytochrome p-450 metabolites; hypertension; non-insulin dependent diabetes mellitus; inflammation; nuclear factor-kb; monocyte chemoattractant protein-1

Document Type: Review article

DOI: http://dx.doi.org/10.2174/157340205774574577

Affiliations: 1: Vascular Biology Center, Medical College of Georgia, 1459 Laney Walker Blvd., Augusta, GA 30912, USA.

Publication date: 2005-11-01

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• Current Hypertension Reviews publishes frontier reviews on all the latest advances on hypertension and its related areas e.g. nephrology, clinical care, and therapy. The journal's aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all clinicians and researchers in the field of hypertension.