HIV-1 Vectors: Fulfillment of Expectations, Further Advancements, and Still A Way To Go

Authors: Cockrell A.S.; Kafri T.

Source: Current HIV Research, Volume 1, Number 4, October 2003 , pp. 419-439(21)

Publisher: Bentham Science Publishers

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Abstract:

The ability of lentiviral vectors to transduce and stably integrate their genomes into non-dividing cells was the major reason for the development of the HIV-1 based vector gene delivery system. The first VSVG pseudotyped lentiviral vectors fulfilled these expectations by ferrying large genetic payloads to nondividing cells in vitro and in vivo. Here we discuss advances in HIV-1 vector systems which lead to improvement in biosafety, transduction efficiency, longevity and regulation of transgene expression, and vector production. The successful use of the advanced HIV-1 based vector system opened new avenues in establishing transgenic animal models for basic research. Additionally, we describe accomplishments using HIV-1 based vectors to correct pathological courses of incurable diseases in preclinical animal models including Parkinson's disease and bgr

-thalassemia.

Keywords: lentiviral vector; gene therapy; animal model; pseudotype; tetracycline

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1570162033485104

Affiliations: 1: UNC gene therapy center, 7119 Thurston-Bowles, CB 7352, Chapel Hill, NC, 27599, USA.

Publication date: 2003-10-01

More about this publication?

Current HIV Research aims to cover all the latest and outstanding developments of HIV research. We invite comprehensive review articles and novel, pioneering work in the basic and clinical fields on all areas of HIV research, including virus replication and gene expression, HIV assembly, virus-cell interaction, viral pathogenesis, epidemiology and transmission, anti-retroviral therapy and adherence, drug discovery, the latest developments in HIV/AIDS vaccines and animal models, mechanisms and interactions with AIDS related diseases, social and public health issues related to HIV disease, and prevention of viral infection. Each issue of the journal contains a series of timely in-depth reviews and original research written by leaders in the field covering a range of current topics on HIV research. Periodically, the journal will invite guest editors to devote an issue on a particular area of HIV research of great interest that increases our understanding of the virus and its complex interaction with the host.

HIV-1 Vectors: Fulfillment of Expectations, Further Advancements, and Still A Way To Go

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