Rodent Models for HIV-1 Infection and Disease

Authors: Maanen M.van; Sutton R.E.

Source: Current HIV Research, Volume 1, Number 1, January 2003 , pp. 121-130(10)

Publisher: Bentham Science Publishers

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Abstract:

The development of a predictive, small animal model for human immunodeficiency virus type 1 (HIV-1) disease would greatly facilitate the analysis of many aspects of viral infection, pathogenesis and treatment. While numerous small animal models exist which emulate various aspects of HIV-1 infection and / or disease in humans, none of these models support robust HIV-1 replication within the context of an intact immune system. Despite this major limitation, these models have helped to elucidate different aspects of HIV-1 pathogenesis in humans. Moreover, recent advances regarding the underlying nature of the blocks to viral replication in non-human cells have raised the possibility that rodents may be engineered to support HIV-1 infection. This review will focus on recent attempts to develop a rodent model for HIV-1 disease, and will also describe currently available systems for studying HIV-1.

Keywords: mouse; rat; hiv-1 animal model; transgenic; xenograft; aids

Language: English

Document Type: Review article

DOI: 10.2174/1570162033352075

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