Applications of Lentiviral Vectors for shRNA Delivery and Transgenesis

Authors: Singer, Oded; Verma, Inder M.

Source: Current Gene Therapy, Volume 8, Number 6, December 2008 , pp. 483-488(6)

Publisher: Bentham Science Publishers

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Abstract:

Lentiviral vectors are potent gene delivery vehicles that enable stable expression of transgenes in both dividing and post-mitotic cells. Development of lentiviral vectors expressing small hairpin RNAs generates a system that can be used to down regulate specific target genes in vivo and in vitro. In this review, we will discuss two examples of in vivo applications for the use of lentiviral vectors expressing shRNAs: Gene therapy of neurological disorders and generation of transgenic knockdown animals.

Keywords: Lentiviral Vectors; Transgenesis; RNAs; Gene therapy; neurological disorders

Document Type: Research article

DOI: http://dx.doi.org/10.2174/156652308786848067

Publication date: 2008-12-01