The Use of Adenoviral Vectors for Genetic Manipulation and Analysis of Primitive Hematopoietic Cells

Authors: Jordan C.T.; Vanin E.F.; Marini F.C.

Source: Current Gene Therapy, Volume 1, Number 3, September 2001 , pp. 257-266(9)

Publisher: Bentham Science Publishers

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Abstract:

Gene transfer into stem cells has long been studied as a means by which primitive hematopoietic cells could be characterized and manipulated. While a variety of strategies have been attempted, it still remains relatively difficult to perform direct stem cell analysis. In this review, we examine recent studies using adenovirus-based vectors as a means to achieve high-level gene transfer into primitive hematopoietic cell types.

Keywords: Adenoviral Vectors; Primitive Hematopoietic Cells; Hematopoietic Gene; Fiber Protein; antibody redirection; Hybrid Vectors; Capsid Proteins

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1566523013348535

Publication date: 2001-09-01