Developmental and Biological Insights Obtained from Gene Expression Profiling of the Nematode Caenorhabditis Elegans

Authors: Reisner, Kaja; Asikainen, Suvi; Vartiainen, Suvi; Wong, Garry

Source: Current Genomics, Volume 6, Number 2, March 2005 , pp. 97-107(11)

Publisher: Bentham Science Publishers

Buy & download fulltext article:

Price: $63.10 plus tax (Refund Policy)

Abstract:

The ability to interrogate gene expression levels of an organism's entire transcriptome has provided researchers with a powerful tool. This power has been brought to bear on biological questions in the areas of development, aging, cell biology, disease models, stress and toxicology. Many novel insights into biological processes have been obtained from these studies and have led to connections to other systems level approaches including RNA interference and bioinformatics. In this article, we review microarray studies that have used the nematode Caenorhabditis elegans. Specific considerations of C. elegans as a model organism in this context are derived and inferences based on combining microarray data sets with other model organisms are presented and discussed. Sources for obtaining microarray data as well as the microarrays themselves are listed. Finally, we take a look into the future of this remarkable and still evolving field of expression profiling in C. elegans.

Keywords: c. elegans; microarrays; expression profiling; rnai; disease models; bioinformatics

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1389202053642294

Affiliations: 1: A.I. Virtanen Institute, Kuopio University, P.O. Box 1627, Kuopio 70211, Finland.

Publication date: 2005-03-01