@article {H.:July 2004:1389-2029:443,
author = "H. Oberkofler",
author = "F. Krempler",
author = "W. Patsch",
title = "PGC-1alpha: A Multifunctional Transcriptional Coactivator Involved in Human Metabolic Disorders",
journal = "Current Genomics",
volume = "5",
year = "July 2004",
abstract = "Nuclear hormone receptor function is controlled by a number of ancillary factors termed coregulators. Such coactivators and corepressors afford considerable flexibility in the coordinate expression of gene networks in numerous physiological, developmental and metabolic processes. PGC-1
, originally described as transcriptional coactivator of PPAR
, has since been shown to act in a much broader context. PGC-1 coordinates the transcriptional programs of several key cellular pathways including mitochondrial biogenesis, thermogenesis, hepatic gluconeogenesis and 
- oxidation of fatty acids via interactions with a growing number of transcription factors. A central issue to understand the diverse functions of PGC-1 is to gain insight into the mechanisms that confer specificity to its interactions with transfactors in response to intra- and extracellular signals. This review focuses on the different modes of regulation of PGC-1 function and the implications for tissue and context-specific transcriptional responses. Moreover, the role of sequence substitutions at the PGC-1 gene locus and their haplotype structure is discussed in relation to human disease phenotypes.",
pages = "443-451(9)",
url = "http://www.ingentaconnect.com/content/ben/cg/2004/00000005/00000005/art00006"
doi = "doi:10.2174/1389202043349129"
}