Viral infection in animals and plants is a serious problem worldwide. It causes dramatic losses in health and economy. Many approaches to combat with viral infectious diseases have been intensively investigated. Measures taken against viral infections can either aim for protecting from viral infection or eliminating the viruses after infection. RNA dependent RNA polymerase (RdRp) is a key enzyme for viral replication and found in all positive strand RNA viruses. Disturbing the RdRp activity therefore results in reducing or inhibiting the virus infection. In this review we focus on reviewing different strategies and agents to inhibit the RdRps of different mammalian and plant positive-sense (ss) RNA viruses. The strategies described in this review are mainly focusing on interference of the nucleotides which are the substrates need for RdRp and blocking the RdRp itself by using chemical agents or antibodies specifically binding to the different domains of the RdRps. Moreover using small interfering (si) RNA technology platform to inhibit the RdRp activity is also discussed.
Document Type: Research Article
Publication date: December 1, 2009
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Current Enzyme Inhibition aims to publish all the latest and outstanding developments in enzyme inhibition studies with regards to the mechanisms of inhibitory processes of enzymes, recognition of active sites, and the discovery of agonists and antagonists, leading to the design and development of new drugs of significant therapeutic value. Each issue contains a series of timely, in-depth reviews written by leaders in the field, covering a range of enzymes that can be exploited for drug development. Current Enzyme Inhibition is an essential journal for every pharmaceutical and medicinal chemist who wishes to have up-to-date knowledge about each and every development in the study of enzyme inhibition.