Inhibition of Disulfide Reductases as a Therapeutic Strategy

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Abstract:

Disulfide reductases are involved in many functions in the cell, in particular, maintaining the intracellular redox balance. Many classes of these enzymes exist, and their inhibition has served as an effective therapy against different types of human diseases. The involvement of disulfide reductases in various cellular processes is reviewed, and therapeutic strategies against pathogenic bacteria, parasitic infections, and human diseases based on their inhibition are discussed.





Keywords: Disulfide reductase; cancer; glutathione; inhibition; pathogen; therapeutic target; thioredoxin

Document Type: Research Article

Publication date: October 1, 2009

More about this publication?
  • Current Enzyme Inhibition aims to publish all the latest and outstanding developments in enzyme inhibition studies with regards to the mechanisms of inhibitory processes of enzymes, recognition of active sites, and the discovery of agonists and antagonists, leading to the design and development of new drugs of significant therapeutic value. Each issue contains a series of timely, in-depth reviews written by leaders in the field, covering a range of enzymes that can be exploited for drug development. Current Enzyme Inhibition is an essential journal for every pharmaceutical and medicinal chemist who wishes to have up-to-date knowledge about each and every development in the study of enzyme inhibition.
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