The Role of CXCR2/CXCR2 Ligands in Acute Lung Injury
Authors: Strieter, Robert M.1; Keane, Michael P.1; Burdick, Marie D.1; Sakkour, Ammar1; Murray, Lynne A.1; Belperio, John A.1
Source: Current Drug Targets - Inflammation & Allergy, Volume 4, Number 3, June 2005 , pp. 299-303(5)
Publisher: Bentham Science Publishers
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Abstract:
The mortality of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) remain high despite advances in our knowledge and intensive care. This supports the contention that we need to further our understanding of the mediators that are involved in the pathogenesis of ARDS. The pathogenesis of ARDS proceeds as a continuum from exudation and inflammation to a fibroproliferative phase of diffuse alveolar damage. While a number of mediators are involved in the pathogenesis of ARDS, members of the CXC chemokine family have been determined to play a critical and pleiotropic role in promoting both recruitment of inflammatory cells, as well as in mediating aberrant vascular remodeling during both phases of ARDS. The importance of the biology of CXC chemokines in ALI/ARDS will be discussed in this review.Keywords: chemokines; cytokines; and acute lung injury
Document Type: Review article
DOI: 10.2174/1568010054022178
Affiliations: 1: Division of Pulmonary, Critical Care Medicine, and Hospitalists, UCLA School of Medicine, 14-154 Warren Hall, 900 Veteran Ave., Los Angeles, CA 90095-1786, USA.
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