Skip to main content

Unconventional Strategies for the Suppression of Allergic Asthma

Buy Article:

$63.00 plus tax (Refund Policy)



Allergic asthma results from an intrapulmonary allergen-driven Th2 response and is characterized by intermittent airway obstruction, airway hyperreactivity, and airway inflammation. An inverse association between allergic asthma and microbial infections has been observed. And this observation constitutes the base of the hygiene hypothesis. Here we discuss the hygiene hypothesis with emphasis on regulatory cells. We review the evidence for the emergence of regulatory cells, such as CD4+CD25+ T cells during infection or during induction of tolerance by mucosal antigen administration. The review focuses also on the emergence of activated CD8+ T cells and macrophages, induced by infections or microbial products, which also can result in the suppression of asthma. The underlying mechanisms by which regulatory immune cells suppress asthma may represent novel unconventional strategies controlling asthma.





No References
No Citations
No Supplementary Data
No Data/Media
No Metrics

Keywords: asthma; hygiene hypothesis; immune deviation; macrophages; regulatory t cells; tlr4 and no; tolerance

Document Type: Review Article

Publication date: 2003-06-01

  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more