Macrophage-Derived IL-18 Targeting for the Treatment of Crohn's Disease

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Abstract:



Crohn's disease is an inflammatory bowel disease associated with several changes in the immune system, including an increased number of infiltrating macrophages. These macrophages release a variety of proinflammatory cytokines, such as tumor necrosis factor-α (TNF-α), macrophage infiltrating factor (MIF), interleukin (IL)-6, IL-12 and IL-18, which are critically involved in the onset and the development of Crohn's disease. We here focus on the role of macrophages, especially macrophagederived IL-18 in both patients with Crohn's disease and a murine model of Crohn's disease.





Keywords: crohns disease; il-18; immunotoxin; proinflammatory cytokines; targeting

Document Type: Review Article

DOI: http://dx.doi.org/10.2174/1568010033484250

Publication date: June 1, 2003

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