Serotonin Transporters

Authors: Inoue T.; Kusumi I.; Yoshioka M.

Source: Current Drug Targets-CNS & Neurological Disorders, Volume 1, Number 5, October 2002 , pp. 519-529(11)

Publisher: Bentham Science Publishers

Abstract:

The serotonin transporter is most well known as the site of action of the serotonin reuptake inhibitors, which were initially developed as antidepressants, but now are the most widely used agents in the treatment of many additional neuropsychiatric and related disorders. The discovery that the serotonin transporter gene possesses a functional polymorphism within the promoter region led to many studies examining this polymorphism in individuals with different neuropsychiatric disorders. These observations raise the possibility of developing a new class of agents with different therapeutic and side effect profiles than conventional drugs. This overview of recent studies of the serotonin transporters attempts to open new areas for discussion and define concepts not yet comprehensively reviewed.

Keywords: Serotonin Transporters; antidepressants; functional polymorphism; neuropsychiatric disorders; sert; personality traits; clinical efficacy

Language: English

Document Type: Review article

DOI: http://dx.doi.org/10.2174/1568007023338987

Publication date: 2002-10-01

• CNS & Neurological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in neurological and central nervous system (CNS) disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal will contain a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in neurological and CNS disorders. As the discovery, identification, characterization and validation of novel human drug targets for neurological and CNS drug discovery continues to grow; this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.

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• In this Subject: Neurology & Psychiatry ,  Pharmacology
• By this author: Inoue T. ;  Kusumi I. ;  Yoshioka M.

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