Targeting the JNK Pathway for Therapeutic Benefit in CNS Disease

Authors: Bozyczko-Coyne D.; Saporito M.S.; Hudkins R.L.

Source: Current Drug Targets-CNS & Neurological Disorders, Volume 1, Number 1, February 2002 , pp. 31-49(19)

Publisher: Bentham Science Publishers

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Abstract:

The c-Jun N-terminal Kinase (JNK) pathway leading to c-Jun phosphorylation plays a causal role in apoptosis of isolated primary embryonic neurons and of multiple neuronal cell lines following a wide variety of stimuli. Activation of this pathway may also contribute to the neuronal atrophy and death that is associated with neurodegenerative pathological conditions including Alzheimer's, Parkinson's, Huntington's Diseases and stroke. Here, the data that providelinks between the activation of the JNK pathway and its potential to play an operative role in CNS disease are reviewed. Also included is the progress on development of inhibitors targeting the JNK pathway for therapeutic benefit.

Keywords: CNS Disease; c-Jun N-terminal Kinase (JNK); Alzheimer; Parkinson; Huntington Diseases; stroke; mixed lineage kinase; (MLK); Inhibitors of; Stress-Activated Kinase Pathway

Language: English

Document Type: Review article

DOI: 10.2174/1568007023339472

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