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Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal will be devoted to a single timely topic, with series of in-depth reviews, written by leaders in the field, covering a range of current topics on drug targets. These issues will be organized and led by a guest editor who is a recognized expert in the overall topic. As the discovery, identification, characterisation and validation of novel human drug targets for drug discovery continues to grow; this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.

Publisher: Bentham Science Publishers

Volume 12, Number 12, November 2011

Articles

Rational Targeting of the Urokinase Receptor (uPAR): Development of Antagonists and Non-Invasive Imaging Probes
pp. 1711-1728(18)
Authors: C. Kriegbaum, M.; Persson, M.; Haldager, L.; Alpizar-Alpizar, W.; Jacobsen, B.; Gardsvoll, H.; Kjaer, A.; Ploug, M.

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Structural Basis for Therapeutic Intervention of uPA/uPAR System
pp. 1729-1743(15)
Authors: Chi Ki Ngo, Jacky; Jiang, Longguang; Lin, Zhonghui; Yuan, Cai; Chen, Zhuo; Zhang, Xu; Yu, Haiyang; Wang, Jundong; Lin, Lin; Huang, Mingdong

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uPAR as Anti-Cancer Target: Evaluation of Biomarker Potential, Histological Localization, and Antibody-Based Therapy
pp. 1744-1760(17)
Authors: K. Lund, Ida; Illemann, Martin; Thurison, Tine; J. Christensen, Ib; Hoyer-Hansen, Gunilla

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Regulation of Cell Migration and Invasion by Specific Modules of uPA: Mechanistic Insights and Specific nhibitors
pp. 1761-1771(11)
Authors: Vincenza Carriero, Maria; Franco, Paola; Votta, Giuseppina; Longanesi-Cattani, Immacolata; Teresa Vento, Maria; Teresa Masucci, Maria; Mancini, Alessandro; Caputi, Mario; Iaccarino, Ingram; Patrizia Stoppelli, Maria

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Current Issues with Glycoprotein IIb-IIIa Antagonists
pp. 1813-1820(8)
Author: J. Schneider, David

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Platelet and Soluble Glycoprotein VI - Novel Applications in Diagnosis and Therapy
pp. 1821-1830(10)
Authors: Bigalke, Boris; Elvers, Margitta; Schonberger, Tanja; Gawaz, Meinrad

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Role of Platelet Function Testing in Clinical Practice: Current Concepts and Future Perspectives
pp. 1836-1847(12)
Authors: Sibbing, Dirk; A. Byrne, Robert; Kastrati, Adnan

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Progress of Antiplatelet Pharmacogenomics
pp. 1848-1858(11)
Author: H. Oestreich, Julie

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Big Science for Small Cells: Systems Approaches for Platelets
pp. 1859-1870(12)
Authors: P. Holly, Stephen; V. Parise, Leslie

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