Vitamin D Biology in Heart Failure: Molecular Mechanisms and Systematic Review
So, epidemiological data and mechanistic studies have provided strong support for a potentially cardioprotective effect of vitamin D. It remains unclear if vitamin D supplementation is beneficial in preventing heart failure or if it could be a therapeutic addendum in the treatment of heart failure. This review summarizes current knowledge on vitamin D and its biology in heart failure.
Keywords: ARAs; CYP24; CYP27B1; Heart failure; NHRs; PPAR; PRA; RAS; Renin-Angiotensin System; Rs4646537; Ultraviolet-B; VDR; VDR signaling; atherosclerosis; chronic obstructive pulmonary disease; diabetes; hBNP; hypertension; hypertrophy; hypocalcaemia; hypovitaminosis; liver X receptor; proBNP; renin; renin-angiotensin system; vitamin D; vitamin D receptor
Document Type: Research Article
Publication date: 2011-01-01
- Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal will be devoted to a single timely topic, with series of in-depth reviews, written by leaders in the field, covering a range of current topics on drug targets. These issues will be organized and led by a guest editor who is a recognized expert in the overall topic. As the discovery, identification, characterisation and validation of novel human drug targets for drug discovery continues to grow; this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.