Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal will be devoted to a single timely topic, with series of in-depth reviews, written by leaders in the field, covering a range of current topics on drug targets. These issues will be organized and led by a guest editor who is a recognized expert in the overall topic. As the discovery, identification, characterisation and validation of novel human drug targets for drug discovery continues to grow; this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.

Publisher: Bentham Science Publishers

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Volume 11, Number 10, October 2010

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Articles

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Multiple Defects in Energy Metabolism in Alzheimer's Disease
pp. 1193-1206(14)
Authors: L. Ferreira, I.; Resende, R.; Ferreiro, E.; C. Rego, A.; F. Pereira, C.

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Metabolic Aspects of Prion Diseases: An Overview
pp. 1207-1217(11)
Authors: Vranac, Tanja; Bresjanac, Mara

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Mitochondrial-Associated Metabolic Changes and Neurodegeneration in Huntington's Disease - from Clinical Features to the Bench
pp. 1218-1236(19)
Authors: R. Rosenstock, Tatiana; I. Duarte, Ana; Cristina Rego, A.

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Hypothalamic and Neuroendocrine Changes in Huntington's Disease
pp. 1237-1249(13)
Authors: Hult, Sofia; Schultz, Kristofer; Soylu, Rana; Petersen, Asa

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The Role of PGC-1α in the Pathogenesis of Neurodegenerative Disorders
pp. 1262-1269(8)
Authors: Rona-Voros, Krisztina; Weydt, Patrick

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Sirtuins: Common Targets in Aging and in Neurodegeneration
pp. 1270-1280(11)
Authors: Machado de Oliveira, Rita; F. Pais, Teresa; Fleming Outeiro, Tiago

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The Mutator Phenotype in Cancer: Molecular Mechanisms and Targeting Strategies
pp. 1296-1303(8)
Authors: J. Prindle, Marc; J. Fox, Edward; A. Loeb, Lawrence

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Genetic and Epigenetic Heterogeneity in Cancer: The Ultimate Challenge for Drug Therapy
pp. 1304-1316(13)
Authors: H. Heng, H.; Liu, G.; B. Stevens, J.; W. Bremer, S.; J. Ye, K.; J. Ye, C.

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Genetic Instability Influences Drug Response in Cancer Cells
pp. 1317-1324(8)
Authors: Damia, G.; D'Incalci, M.

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Targeting Synthetic Lethality in DNA Damage Repair Pathways as an Anti-Cancer Strategy
pp. 1336-1340(5)
Authors: J. Moeller, Benjamin; Arap, Wadih; Pasqualini, Renata

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Targeting Karyotypic Complexity and Chromosomal Instability of Cancer Cells
pp. 1341-1350(10)
Authors: V. Roschke, Anna; R. Kirsch, Ilan

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