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Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal will be devoted to a single timely topic, with series of in-depth reviews, written by leaders in the field, covering a range of current topics on drug targets. These issues will be organized and led by a guest editor who is a recognized expert in the overall topic. As the discovery, identification, characterisation and validation of novel human drug targets for drug discovery continues to grow; this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.

Publisher: Bentham Science Publishers

Volume 9, Number 9, September 2008

Articles

Structure and Mechanism of Drug Efflux Machinery in Gram Negative Bacteria
pp. 719-728(10)
Authors: Pietras, Zbigniew; Bavro, Vassiliy N.; Furnham, Nicholas; Pellegrini-Calace, Marialuisa; Milner-White, E. J.; Luisi, Ben F.

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The AcrB Efflux Pump: Conformational Cycling and Peristalsis Lead to Multidrug Resistance
pp. 729-749(21)
Authors: Seeger, Markus A.; Diederichs, Kay; Eicher, Thomas; Brandstatter, Lorenz; Schiefner, Andre; Verrey, Francois; Pos, Klaas M.

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Membrane Permeability and Regulation of Drug “Influx and Efflux” in Enterobacterial Pathogens
pp. 750-759(10)
Authors: Davin-Regli, Anne; Bolla, Jean-Michel; James, Chloe E.; Lavigne, Jean-Philippe; Chevalier, Jacqueline; Garnotel, Eric; Molitor, Alexander; Pages, Jean-Marie

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New Methods for the Identification of Efflux Mediated MDR Bacteria, Genetic Assessment of Regulators and Efflux Pump Constituents, Characterization of Efflux Systems and Screening for Inhibitors of Efflux Pumps
pp. 760-778(19)
Authors: Viveiros, M.; Martins, M.; Couto, I.; Rodrigues, L.; Spengler, G.; Martins, A.; Kristiansen, J. E.; Molnar, J.; Amaral, L.

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Physical Insights into Permeation of and Resistance to Antibiotics in Bacteria
pp. 779-788(10)
Authors: Ceccarelli, Matteo; Ruggerone, Paolo

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Biophysical Characterization of In- and Efflux in Gram-Negative Bacteria
pp. 789-796(8)
Authors: Weingart, Helge; Petrescu, Mircea; Winterhalter, Mathias

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Antimicrobial Resistance in Foodborne Pathogens - A Cause for Concern?
pp. 808-815(8)
Authors: Walsh, Ciara; Fanning, Seamus

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Promising Therapy of XDR-TB/MDR-TB with Thioridazine an Inhibitor of Bacterial Efflux Pumps
pp. 816-819(4)
Authors: Amaral, L.; Martins, M.; Viveiros, M.; Molnar, J.; Kristiansen, J. E.

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