The Host Complement System and Arbovirus Pathogenesis

Authors: Morrison, T. E.; Heise, M. T.

Source: Current Drug Targets, Volume 9, Number 2, February 2008 , pp. 165-172(8)

Publisher: Bentham Science Publishers

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Abstract:

Arthropod-borne viruses (arboviruses) are a significant cause of human diseases worldwide. Interactions between these viruses and the innate immune system play a major role in determining the outcome of disease. The complement system is particularly important in this process as activation of complement can contribute to both host defense as well as injury to host tissues. This review focuses on the increasing evidence that the complement system plays key roles in both protective and pathologic outcomes of arbovirus infection.

Keywords: Arbovirus; viral pathogenesis; alphavirus; flavivirus; complement

Document Type: Research article

Publication date: 2008-02-01

More about this publication?

Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal will be devoted to a single timely topic, with series of in-depth reviews, written by leaders in the field, covering a range of current topics on drug targets. These issues will be organized and led by a guest editor who is a recognized expert in the overall topic. As the discovery, identification, characterisation and validation of novel human drug targets for drug discovery continues to grow; this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.