Lipases as Modulators of Atherosclerosis in Murine Models

Authors: Brown, Robert J.; Rader, Daniel J.

Source: Current Drug Targets, Volume 8, Number 12, December 2007 , pp. 1307-1319(13)

Publisher: Bentham Science Publishers

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Abstract:

Lipoprotein lipase, hepatic lipase, and endothelial lipase are sn-1 lipases that play important roles in the metabolism of plasma lipoproteins. In vitro and in vivo studies suggest that these lipases exhibit both pro- and antiatherogenic properties, which are dependent primarily on their tissue localization. The following chapter reviews the physiology of these lipases, and the consequences of the loss or gain of function for each lipase in modulating atherosclerosis, with emphasis on murine models.

Keywords: Lipase; lipoprotein; aortic lesion; coronary artery disease; atherosclerosis; transgenic mouse; knockout mouse

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138945007783220614

Publication date: 2007-12-01

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Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal will be devoted to a single timely topic, with series of in-depth reviews, written by leaders in the field, covering a range of current topics on drug targets. These issues will be organized and led by a guest editor who is a recognized expert in the overall topic. As the discovery, identification, characterisation and validation of novel human drug targets for drug discovery continues to grow; this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.