Cytokines as Regulators of Atherosclerosis in Murine Models

Authors: Mallat, Ziad; Tedgui, Alain

Source: Current Drug Targets, Volume 8, Number 12, December 2007 , pp. 1264-1272(9)

Publisher: Bentham Science Publishers

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Abstract:

Atherosclerosis is a chronic inflammatory disease of the arterial wall initiated by a variety of pro-atherogenic stimuli, such as modified epitopes of phospholipids. Both innate and adaptive immune responses contribute to disease initiation and progression. Here, we review the major cytokines involved in this immuno-inflammatory response, and shown to significantly impact disease initiation and/or progression in murine models. We particularly emphasize the role of the regulatory arm of the immune response in disease modulation, and review the major factors that may be involved in its promotion or alteration.

Keywords: TNF receptors; inflammatory response; CD40 receptor; Signaling Pathways; Leptin

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138945007783220588

Publication date: 2007-12-01

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Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal will be devoted to a single timely topic, with series of in-depth reviews, written by leaders in the field, covering a range of current topics on drug targets. These issues will be organized and led by a guest editor who is a recognized expert in the overall topic. As the discovery, identification, characterisation and validation of novel human drug targets for drug discovery continues to grow; this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.