Oxidative Stress as a Regulator of Murine Atherosclerosis

Authors: Hsiai, Tzung; Berliner, Judith A.

Source: Current Drug Targets, Volume 8, Number 12, December 2007 , pp. 1222-1229(8)

Publisher: Bentham Science Publishers

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Abstract:

Altered cellular production of reactive oxygen species (ROS) and/or reactive nitrogen species (RNS) is a ubiquitous feature of human disease. Vascular oxidative stress is a unifying area of research in atherosclerosis and aging. While elevated levels of ROS, especially oxygen radicals (O2 -·) and hydrogen peroxide (H2O2), induce cellular apoptosis, low levels play an important role in cell signaling [1,2]. Reactive species from a variety of sources further play an important role in plaque disruption partly through lipid oxidation, low-density lipoprotein oxidation nitration, and signaling [3- 6].

Keywords: NADPH Oxidase; dihydroethidium; superoxide dismutase; Lipoxygenase; xanthine oxidase

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138945007783220678

Publication date: 2007-12-01

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Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal will be devoted to a single timely topic, with series of in-depth reviews, written by leaders in the field, covering a range of current topics on drug targets. These issues will be organized and led by a guest editor who is a recognized expert in the overall topic. As the discovery, identification, characterisation and validation of novel human drug targets for drug discovery continues to grow; this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.