Author: Jose Rafael Romero,

Source: Current Drug Targets, Volume 8, Number 7, July 2007 , pp. 794-801(8)

Publisher: Bentham Science Publishers

Abstract:

Stroke prevails as a common and devastating disease. Epidemiological studies have advanced our understanding of stroke risk factors and clinical trials have demonstrated effective interventions to decrease stroke risk by modifying risk factors. Stroke risk factors are classified as traditional and novel and may be further divided into modifiable and non-modifiable. In this review we discuss select traditional risk factors for ischemic stroke, interventions for primary and secondary prevention and areas of research progress. Stroke treatment should be comprehensive, involving patient, community and medical personnel education, evaluation of individual risk factors and overall stroke risk assessment. Ongoing research is exploring further interventions in the management of traditional risk factors. Future research will expand our knowledge about the contribution of genetic factors to stroke, their interaction with environmental factors and open exciting avenues for the development of new therapies.

Keywords: Framingham Stroke Risk Profile; Atrial fibrillation; Hypertension; diabetes; Hyperlipidemia; obesity

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138945007781077373

Publication date: 2007-07-01

More about this publication?

• Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal will be devoted to a single timely topic, with series of in-depth reviews, written by leaders in the field, covering a range of current topics on drug targets. These issues will be organized and led by a guest editor who is a recognized expert in the overall topic. As the discovery, identification, characterisation and validation of novel human drug targets for drug discovery continues to grow; this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.

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