Lipid Management and Peripheral Arterial Disease

Authors: Daskalopoulou, S. S.; Daskalopoulos, M. E.; Mikhailidis, D. P.; Liapis, C. D.

Source: Current Drug Targets, Volume 8, Number 4, April 2007 , pp. 561-570(10)

Publisher: Bentham Science Publishers

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Abstract:

Peripheral arterial disease (PAD) is a common disorder usually associated with silent or symptomatic arterial disease elsewhere in the circulation and a “cluster” of cardiovascular risk factors (e.g. smoking, dyslipidemia, hypertension, and insulin resistance/ diabetes mellitus). The medical management of PAD should focus on both the relief of symptoms and prevention of secondary cardiovascular complications. This approach must include smoking cessation, optimal cholesterol levels, blood pressure and glycemic control as well as prescribing antiplatelet therapy.

This review focuses on the evidence supporting the use of lipid-lowering drugs in PAD. Several trials indicate that getting low density lipoprotein-cholesterol levels to target (<2.6 mmol/l; 100 mg/dl), or even lower, is associated with improvement of symptoms and a reduction in vascular events in patients with PAD.

Keywords: Peripheral arterial disease; risk factors; dyslipidemia; lipid lowering; statins; prevention

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138945007780362737

Affiliations: 1: Department of Clinical Biochemistry (Vascular Disease Prevention Clinics), Royal Free Hospital,Royal Free and University College School of Medicine, (University of London),Pond Street, London NW3 2QG, UK.

Publication date: 2007-04-01

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Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal will be devoted to a single timely topic, with series of in-depth reviews, written by leaders in the field, covering a range of current topics on drug targets. These issues will be organized and led by a guest editor who is a recognized expert in the overall topic. As the discovery, identification, characterisation and validation of novel human drug targets for drug discovery continues to grow; this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.

Lipid Management and Peripheral Arterial Disease

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