Endothelium as a Therapeutic Target in Sepsis

Author: Aird, William C.¹

Source: Current Drug Targets, Volume 8, Number 4, April 2007 , pp. 501-507(7)

Publisher: Bentham Science Publishers

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Abstract:

The endothelium plays an important role in health and disease. Endothelial dysfunction contributes to sepsis pathophysiology. An important goal is to develop novel therapies that reverse endothelial dysfunction in sepsis. This review will consider the role of the endothelium in sepsis and will highlight its untapped therapeutic potential.

Keywords: sepsis; Toll-like receptor; macrophage; protease activated receptor; endothelial phenotype; VCAM

Document Type: Research article

DOI: 10.2174/138945007780362782

Affiliations: 1: Molecular Medicine, Beth Israel Deaconess Medical Center, RW-663, 330 Brookline Avenue, Boston, MA 02215, USA.

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