Endothelium as a Therapeutic Target in Sepsis

Author: Aird, William C.

Source: Current Drug Targets, Volume 8, Number 4, April 2007 , pp. 501-507(7)

Publisher: Bentham Science Publishers

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Abstract:

The endothelium plays an important role in health and disease. Endothelial dysfunction contributes to sepsis pathophysiology. An important goal is to develop novel therapies that reverse endothelial dysfunction in sepsis. This review will consider the role of the endothelium in sepsis and will highlight its untapped therapeutic potential.

Keywords: sepsis; Toll-like receptor; macrophage; protease activated receptor; endothelial phenotype; VCAM

Document Type: Research article

DOI: http://dx.doi.org/10.2174/138945007780362782

Affiliations: 1: Molecular Medicine, Beth Israel Deaconess Medical Center, RW-663, 330 Brookline Avenue, Boston, MA 02215, USA.

Publication date: 2007-04-01

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Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal will be devoted to a single timely topic, with series of in-depth reviews, written by leaders in the field, covering a range of current topics on drug targets. These issues will be organized and led by a guest editor who is a recognized expert in the overall topic. As the discovery, identification, characterisation and validation of novel human drug targets for drug discovery continues to grow; this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.